Search on: B7-2 COSTIMULATORY MOLECULE 
Descriptors Found: 1
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Descriptor English:   Antigens, CD86 
Descriptor Spanish:   Antígenos CD86 
Descriptor Portuguese:   Antígenos CD86 
Synonyms English:   Antigen, B7-2
B7-2 Antigen
B70 Costimulatory Molecule
CD86 Antigen
Early T Cell Costimulatory Molecule 1
Antigen, B7 2
Antigen, CD86
B7 2 Antigen
Costimulatory Molecule, B7-2
Costimulatory Molecule, B70
B7-2 Costimulatory Molecule
CD86 Antigens  
Tree Number:   D12.776.467.150.200
D12.776.543.095.200
D23.050.301.264.035.276.200
D23.050.301.285.200
D23.101.100.110.276.200
D23.529.168.200
Definition English:   A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE. 
See Related English:   Immunoglobulin Domains
 
History Note English:   2006(1993) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   51076 
Unique Identifier:   D051940 

Occurrence in VHL: 		 

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